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Expand the sections below to learn more about these steps in mcas diagnosis. · mast cell activation syndrome, also called mcas or mast cell activation disorder, is a condition that causes mast cells to release high amounts of chemicals into your body. Mcas is an immunological condition in which mast cells, a type of white blood cell, inappropriately and excessively release chemical mediators, such as histamine, resulting in a range of chronic symptoms, sometimes including anaphylaxis or near-anaphylaxis attacks. [2][3][4] primary symptoms include cardiovascular, dermatological. · mast cell activation syndrome (mcas) is when your mast cells overreact with no known trigger. Mast cell activation syndrome (mcas) causes a person to have repeated severe allergy symptoms affecting several body systems. It causes severe symptoms and can lead to life-threatening anaphylaxis. Mcas is condition that involves the activation of mast cells, a type of immune cell that plays a role in the bodys response to allergens and other triggers. Mast cell activation syndrome (mcas) is increasingly appearing to be the bulk of the iceberg of mast cell activation diseases (mcad), all of which share the common theme of inappropriate mast cell activation. Mast cell activation syndrome (mcas) is the most common type of mast cell disease. Mcas is a condition in which the patient experiences repeated episodes of the symptoms of anaphylaxis – allergic symptoms such as hives, swelling, low blood pressure, difficulty breathing and severe diarrhea. Learn how to identify and alleviate symptoms of mast cell activation syndrome (mcas). These papers are key resources for diagnostic tests, outlining the utility of measuring urinary metabolites of mast cell mediators in systemic mastocytosis and mast cell activation syndrome. In mcas, mast cells mistakenly release too many chemical agents, resulting in symptoms in the skin, gastrointestinal tract, heart, respiratory, and neurologic systems. · inflammation flares can be confusing.