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Computing to write or rewrite (the instructions in a program) so as to … The meaning of optimize is to make as perfect, effective, or functional as possible. Definition of optimize verb in oxford advanced learners dictionary. See examples of optimize used in a sentence. Find 53 different ways to say optimize, along with antonyms, related words, and example sentences at thesaurus. com. To make the best of. How to use optimize in a sentence. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. · optimize (third-person singular simple present optimizes, present participle optimizing, simple past and past participle optimized) (originally intransitive) to act … To optimize a plan, system, or machine means to arrange or design it so that it operates as smoothly and efficiently as possible. To make something as good as possible: Op•ti•mize (op′ tə mīz′), v. , -mized, -miz•ing. To make as perfect or effective as possible. Learn how to improve windows pc performance if your device is running slowly. To make as effective, perfect, or useful as possible.