The Stat3 Pathway A Deeper Dive Into Pancreatic Cancer Drug Resistance

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· in some ways, the role of stat3 in pdac may hold greater importance than that of oncogenic kirsten rat sarcoma virus (kras). In this review, the current knowledge of stat3 in pancreatic cancer has been summarized, particularly relating to stat3 activation in cancer cells, cells of the tme, and the state of … Campos and shepard et al. · this is the first report of evaluating a chemical inhibitor of stat3 on pancreatic cancer with promising outcomes that sheds light on our understanding of the pathophysiology of … · though only a few trials have shown the efficacy in a clinical setting, the stat3 pathway remains a promising drug target for future treatment of pancreatic ductal … · overall, we found that stat3 significantly predicted cancer prognosis, drug resistance, and immunotherapy, providing a rationale for further experimental studies. Report that hypoxia and inflammatorycytokines activate the stat3/integrinβ3 axis, promoting stress tolerance and accelerating pancreatic cancer initiation … · the study reveals how the stat3 protein, a well-known master regulator of gene expression, enables cancer cells to become more aggressive and evade therapy in response to … · campos and shepard et al. Report that hypoxia and inflammatory cytokines activate the stat3/integrin β3 axis, promoting stress tolerance and accelerating pancreatic cancer … Though only a few trials have shown the efficacy in a clinical setting, the stat3 pathway remains a promising drug target for future treatment of pancreatic ductal adenocarcinoma and may help … This makes stat3 a highly attractive target for … · the stat3 activation regulates these metabolic reprogramming through the transcriptional regulation of genes involved in these processes, which contribute to multiple …