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Fatty, cholesterol-containing deposits build up over time, forming plaques in the hearts arteries. · coronary artery disease, other heart problems and previous heart surgery. It causes the heart to have a harder time pumping blood to the rest of the body, which can lead to symptoms of heart failure. · a heart attack occurs when an artery that sends blood and oxygen to the heart is blocked. · symptoms of heart disease in the blood vessels coronary artery disease is a common heart condition that affects the major blood vessels that supply the heart muscle. A buildup of fats, cholesterol and other substances in and on the artery walls usually causes coronary artery disease. · learn about symptoms, causes and treatment of cardiovascular disease, a term describing a wide range of conditions that can affect the heart. The clot can block arteries, causing a heart attack. Narrowed heart arteries, a heart attack, heart valve disease, prior heart surgery, heart failure, cardiomyopathy and other heart damage are risk factors for almost any kind of arrhythmia. During a heart attack, a lack of blood flow causes the tissue in the heart muscle to die. This buildup is called plaque. · cardiomyopathy (kahr-dee-o-my-op-uh-thee) is a disease of the heart muscle. If a plaque ruptures, a blood clot can form.